5-year follow-up study of children with low-to-moderate lead absorption: electrophysiological evaluation |
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| Authors: | D Otto G Robinson S Baumann S Schroeder P Mushak D Kleinbaum L Boone |
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| Affiliation: | 1. National Research Base of Intelligent Manufacturing Service (Chongqing Technology and Business University), Chongqing Technology and Business University, Chongqing 400067, China;2. Key Laboratory of Complex System Safety and Control (Chongqing University), Ministry of Education, Chongqing 400044, China;3. School of Automation, Chongqing University, Chongqing 400044, China;4. Key Lab for OCME, School of Mathematical Sciences, Chongqing Normal University, Chongqing 400047, China;5. Department of Mechanical Engineering, Universidad Politécnica Salesiana, Cuenca, Ecuador;6. School of Automation, Hangzhou Dianzi University, Hangzhou 310018, China;1. Institute for Risk and Uncertainty, University of Liverpool, United Kingdom;2. Agency for Petroleum, Natural Gas and Biofuels (ANP), Brazil;3. University of Nottingham, United Kingdom;4. Leibniz Universität Hannover, Germany;5. Tongji University, China;6. Department Civil and Environmental Engineering, Centre for Intelligent Infrastructure, Strathclyde University, United Kingdom;1. Faculty of Business & Economics, Macquarie University, 4 Eastern Road, Sydney, NSW 2109, Australia;2. Waikato Management School, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand;3. QUT Business School, Queensland University of Technology, GPO Box 2434, Brisbane, Qld 4001, Australia |
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| Abstract: | Forty-nine children aged 6 to 12 years were evaluated for residual effects of lead exposure using psychometric, electrophysiological, and medical tests 5 years after initial assessment. The original range of blood lead (PbB) levels was 6-59 (mean = 28) micrograms/dl; the current range was 6-30 (mean = 14) micrograms/dl. A linear relationship between PbB and slow brain wave voltage during sensory conditioning was observed at initial evaluation and at 2-year follow-up. No significant relationship between PbB and slow wave voltage during passive conditioning was found at the 5-year follow-up, although a linear increase in slow wave negativity relative to the current PbB level during active conditioning was suggested by exploratory analyses. Another exploratory analysis revealed a significant linear relationship between the original PbB levels and the latency of waves III and V of the brainstem auditory evoked potential. The latency of both waves increased as a function of original PbB. Increased latency of these waves is suggestive of subclinical pathology of the auditory pathway rostral to the cochlear nucleus, although end-organ impairment cannot be ruled out. No threshold for the effect of Pb on auditory function was apparent. |
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