| 老年大鼠心肌缺血再灌注损伤的缺血后处理保护 |
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| 引用本文： | 殷忠,高好考,王海昌,杨晔.老年大鼠心肌缺血再灌注损伤的缺血后处理保护[J].心肺血管病杂志,2011,30(1):58-61,66. |
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| 作者姓名： | 殷忠 高好考 王海昌 杨晔 |
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| 作者单位： | 1. 海军总医院,心脏中心一科,北京,100048
2. 西京医院,心内科 |
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| 摘 要： | 目的:评价老年大鼠急性心肌缺血再灌注后的损伤以及缺血后处理的保护作用,并比较与成年大鼠之间的区别.方法:成年及老年雄性SD大鼠,左侧开胸,建立心肌缺血/再灌注模型.实验共分为6组,成年及老年大鼠各3组(n=8/成年组,n=6/老年组):成年大鼠缺血再灌注组(I/Radult)及老年大鼠缺血再灌注组(I/Raged);成...
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| 关 键 词： | 缺血后处理 老年 缺血/再灌注损伤 心肌保护 |
Ischemic postconditioning protects aged rat hearts against acute ischemia/reperfusion injury |
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| YIN Zhong,GAO Haokao,WANG Haichang,YANG Ye.Ischemic postconditioning protects aged rat hearts against acute ischemia/reperfusion injury[J].Journal of Cardiovascular and Pulmonary Diseases,2011,30(1):58-61,66. |
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| Authors: | YIN Zhong GAO Haokao WANG Haichang YANG Ye |
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| Institution: | YIN Zhong,GAO Haokao,WANG Haichang,YANG Ye Department of Cardiology,Navy General Hospital of Chinese PLA,Beijing 100048,China |
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| Abstract: | Objective:The present study was designed to test the hypothesis that IPost protects against I/R injury in aged hearts.Methods:In vivo hearts from adult(3-4 months) Sprague Dawley(SD) rats or aged(16-18 months) SD rats were subjected to 30 minutes ischemia followed by 3 hours of reperfusion.The rats were assigned to one of the following groups based upon the intervention performed(n = 8 per adult group,n = 6 per aged group):(1) I/Radult and I/Raged: received no other intervention either before or after LAD o... |
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| Keywords: | Ischemic postconditioning Aging Ischemia/reperfusion injury Cardioprotection |
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