| 阿昔莫司和阿托伐他汀对血浆脂蛋白(a)作用的比较 |
| |
| 引用本文： | 王冠,李艳芳.阿昔莫司和阿托伐他汀对血浆脂蛋白(a)作用的比较[J].心肺血管病杂志,2011,30(1):4-7. |
| |
| 作者姓名： | 王冠 李艳芳 |
| |
| 作者单位： | 1. 北京中医药大学第三附属医院
2. 北京首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所12病房,100029 |
| |
| 摘 要： | 目的:对比观察阿昔莫司与阿托伐他汀对血浆脂蛋白(a)lipoprotein(a),Lp(a)]水平的影响,并探讨其作用机制。方法:将血浆Lp(a)水平>300 mg/L的患者213例随机分为阿昔莫司治疗组(n=100),给予阿昔莫司250 mg,2次/d,口服,阿托伐他汀治疗组(n=113),口服阿托伐他汀10 mg,每晚1次,服药前及服药第4 w和第8 w后监测血浆Lp(a)的血浆水平。结果:服药后2组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、Lp(a)的血浆水平均明显降低(P<0.0001),高密度脂蛋白胆固醇(HDL-C)轻度升高(P>0.05)。服药4 w后,阿昔莫司组Lp(a)水平降至(410.00±130.00)mg/L,较服药前下降12.77%;阿托伐他汀组Lp(a)水平降至(460.00±130.00)mg/L,较服药前下降4.17%;2组Lp(a)水平比较差异有统计学意义(P<0.0001)。服药8周后,阿昔莫司组Lp(a)水平平均降至(370.00±120.00)mg/L,较服药前下降21.28%;阿托伐他汀组Lp(a)水平降至(440.00±120.00)mg/L,较服药前下降8.33%;2组Lp(a)水平比较差异有统计学意义(P<0.0001)。结论:阿昔莫司降Lp(a)的疗效明显优于阿托伐他汀。
|
| 关 键 词： | 脂蛋白(a) 阿昔莫司 阿托伐他汀 动脉硬化 |
Effect of acipimox and atorvastatin on the serum lipoprotein(a) |
| |
| WANG Guan,LI Yanfang.Effect of acipimox and atorvastatin on the serum lipoprotein(a)[J].Journal of Cardiovascular and Pulmonary Diseases,2011,30(1):4-7. |
| |
| Authors: | WANG Guan LI Yanfang |
| |
| Institution: | WANG Guan,LI Yanfang. Department of Car-diology,Capital Medical University affiliated Beijing Anzhen Hospital,Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing 100029,China |
| |
| Abstract: | Objective:To observe the effect of acipimox and atorvastatin on the serum lipoprotein(a) and to explore their individual mechanisms.Methods:Of 213 patients whose level of serum lipoprotein(a) was above 0.3mg/dl,100 cases were randomly distributed to the acipimox group,and another 113 cases were randomly distributed to the atorvastatin group.The patients were orally treated by the acipimox 250 mg bid and atorvastatin 10mg qn separately.Subsequently,the survey of serum level of lipoprotein(a) was carried out ... |
| |
| Keywords: | Lipoprotein(a) Acipimox Atorvastatin Atherosclerosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
