| 埃索美拉唑对体外循环心脏手术应激性溃疡保护作用的临床观察 |
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| 引用本文： | 饶丹,张勤斌,王嬿,黄圆琴,罗能贞,陈绪发.埃索美拉唑对体外循环心脏手术应激性溃疡保护作用的临床观察[J].心肺血管病杂志,2011,30(1):17-19. |
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| 作者姓名： | 饶丹 张勤斌 王嬿 黄圆琴 罗能贞 陈绪发 |
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| 作者单位： | 心脏科,武汉亚洲心脏病医院,430022 |
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| 摘 要： | 目的:探讨埃索美拉唑对体外循环(CPB)心脏手术应激性溃疡的保护作用。方法:208例在体外循环下行瓣膜成形术和/或瓣膜置换术的心脏瓣膜病及需行冠状动脉搭桥(CABG)术的冠心病患者及需行心脏矫治术的先天性心脏病(先心病)患者,随机分为2组,对照组96例给予常规治疗,埃索美拉唑组112例,术前给予口服埃索美拉唑片40 mg/d,1 w;术中静注埃索美拉唑注射液40 mg,1次/d;术后静注埃索美拉唑注射液40 mg/d,3 d;分别于术前测大便OB试验1次,术后4h、术后第1天、术后第2天测胃黏膜pH值(pHi)。结果:埃索美拉唑组手术后4 h、术后第1天术后第2天测胃黏膜pH值(pHi)分别为6.01±0.64,6.32±0.59及6.58±0.39,而对照组手术后4 h、术后第1天、术后第2天测胃黏膜pH值(pHi)分别为3.21±0.22,3.67±0.34及3.43±0.41,与对照组比较,埃索美拉唑组pHi值明显高于对照组(P<0.01)。结论:埃索美拉唑可预防CPB心脏手术应激性溃疡。
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| 关 键 词： | 埃索美拉唑 体外循环 心脏外科手术 应激性溃疡 胃肠道保护 |
Clinical observation on prevention of stress ulcer with esomeprazole in cardio-pulmonary bypass heart surgery |
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| RAO Dan,ZHANG Qinbing,WANG Yan,HUANG Yuanqin,LUO Nengzhen,CHEN Xufa.Clinical observation on prevention of stress ulcer with esomeprazole in cardio-pulmonary bypass heart surgery[J].Journal of Cardiovascular and Pulmonary Diseases,2011,30(1):17-19. |
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| Authors: | RAO Dan ZHANG Qinbing WANG Yan HUANG Yuanqin LUO Nengzhen CHEN Xufa |
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| Institution: | RAO Dan,ZHANG Qinbing,WANG Yan,HUANG Yuanqin,LUO Nengzhen,CHEN Xufa Depart-ment of Cardiac Diseases,Wuhan Asia Heart Hospital,Wuhan 430022,China |
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| Abstract: | Objective: To observe the prevention of stress ulcer with esomeprazole in cardio-pulmonary bypass(CPB) heart surgery.Methods:208 patients who suffered valvular heart disease were scheduled to val-voplasty and/or valve replacement surgery undergoing CPB and who suffered coronary heart disease(CHD) were scheduled to coronary artery bypass grafting(CABG) surgery undergoing CPB and who suffered congenital cardi-ovascular disease were scheduled to heart rectification surgery undergoing CPB.They were randomized i... |
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| Keywords: | Esomeprazole Cardio-pulmonary bypass Cardiac surgical procedures Stress ulcer Gas-trointestial tract protection |
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