L-硝基精氨酸与L-精氨酸干预对大鼠创伤性面瘫恢复的影响

 目的 研究组成型一氧化氮合酶抑制剂L-硝基精氨酸和一氧化氮前体L-精氨酸对大鼠创伤性面瘫恢复的影响.方法 通过大鼠面瘫前后腹膜内小剂量给予L-硝基精氨酸或L-精氨酸,在伤后各个时间点上观察面瘫的恢复.结果 L-硝基精氨酸慢性给药可显著延缓创伤性面瘫的恢复,而小剂量L-精氨酸慢性给药则可显著促进创伤性面瘫的恢复.结论 内源性NO介质在创伤性面瘫模型中具有显著的促面瘫恢复作用.

Effects of L- nitroarginine L- arginine on recovery of traumatic facial paralysis

Objective To study the effects of constitutive NOS inhibitor,L-nitroarginine and NO precursor,L-arginine on the recovery of traumatic facial paralysis in rats.Methods Rats were injected small doses of L-nitroarginine and L-arginine intraperitoneally before and after traumatic facial paralysis,and the recovery of facial paralysis was observed at different time.Results Chronic administration of L-nitroarginine could remarkably inhibit the recovery of traumatic facial paraysis,while chronic administration of L-arginine could remarkably promote it.Conclusions Endogenous nitric oxide mediator may play an obvious role in promoting the recovery of traumatic facial paralysis.