Bacterial antigens in synovial biopsy specimens in yersinia triggered reactive arthritis. |
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Authors: | R Merilahti-Palo K O S?derstr?m R Lahesmaa-Rantala K Granfors A Toivanen |
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Affiliation: | Department of Medicine, Turku University, Finland. |
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Abstract: | Non-viable structures of Yersinia enterocolitica O:3 were shown at the site of inflammation within mononuclear cells in the synovial membrane of eight out of 10 patients with yersinia triggered reactive arthritis. An avidin-biotin-peroxidase complex method, with a rabbit antiserum specific for Y enterocolitica O:3, was used to visualise yersinia structures. All 13 control samples were negative except for one with non-specific mast cell staining. The findings emphasise the significance of foreign material in the initiation of synovitis in reactive arthritis. |
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