| HPLC法对喃氟啶静脉脂肪乳剂化学稳定性的研究 |
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| 引用本文： | 韩继洪,王立群,苏德森. HPLC法对喃氟啶静脉脂肪乳剂化学稳定性的研究[J]. 沈阳药科大学学报, 1993, 0(3) |
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| 作者姓名： | 韩继洪 王立群 苏德森 |
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| 作者单位： | 沈阳药学院物理药学研究室(韩继洪，王立群)，沈阳药学院物理药学研究室(苏德森) |
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| 摘 要： | 本文采用高效液相色谱法测定FT-207及其分解产物5-Fu,对FT-207静脉脂肪乳剂的化学稳定性进行了研究。结果发现在各种pH值条件下FT-207的分解都属于一级反应,且分解速率较FT-207慢得多。FT-207在静脉脂肪乳剂中的分解活化能为118.6kJmol~(-1),有效期为147.8d.
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| 关 键 词： | FT-207 静脉脂肪乳 HPLC法 化学稳定性 |
A STUDY ON THE CHEMICAL STABILITY OF FT-207 INTRAVENOUS FAT EMULSION BY HPLC METHOD |
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| Han Jihong Wang Liqnn Su Desen Res. Dept.of Phy.Pharm.. A STUDY ON THE CHEMICAL STABILITY OF FT-207 INTRAVENOUS FAT EMULSION BY HPLC METHOD[J]. Journal of Shenyang Pharmaceutical University, 1993, 0(3) |
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| Authors: | Han Jihong Wang Liqnn Su Desen Res. Dept.of Phy.Pharm. |
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| Affiliation: | Han Jihong Wang Liqnn Su Desen Res. Dept.of Phy.Pharm. |
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| Abstract: | This article reports the chemical stability of FT-207 in intravenous fat emulsion. The concentration of FT-207 and its decomposition product 5-Fu was measured by HPLC method. It was found that the decomposition of FT-207 is a first order reaction at various pH values and the rate constant decreases with the increase of pH value. Decomposition rate of 5-Fu is much slower than that of FT-207. Activation energy and shelf life of FT-207 in fat emulsion are 118.96KJ/mol and 147.8 days, respectively. |
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| Keywords: | FT-207 Intravenous fat emulsion HPLC method Chemical stability |
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