Inhibitory Effects of Quercetin on Angiogenesis of Experimental Mammary Carcinoma |
| |
摘 要: |
|
关 键 词: | 栎精 乳腺癌 实验研究 抑制机制 |
收稿时间: | 31 August 2004 |
修稿时间: | 8 April 2005 |
Inhibitory effects of quercetin on angiogenesis of experimental mammary carcinoma |
| |
Authors: | Lingquan Kong Kainan Wu HUI lin |
| |
Institution: | Department of General Surgery,the First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing,China,400016 |
| |
Abstract: | OBJECTIVE To explore the inhibitory effects of quercetin on angiogenesis of experimental mammary carcinoma.METHODS A 7,12-dimethylbenzanthracene (DMBA)-induced animal model of mammary carcinoma was established in rats. Seventy-nine female Sprague-Dawly rats were randomized into 4 groups namely, DMBA, DMBA with tamoxifen (TAM), DMBA with quercetin and control agents identified as group A, B, C and D respectively. Treatment was for 28 weeks. Samples of breast tissues were collected for histopathological observation and microvessel density (MVD) estimation by light microscopy. The expression of basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and the protein product of H-ras were examined by immunohistochemical staining.tumor diameter of group A (76.2%, 2.37cm) were significantly higher than that in group B (40.9%, 1.82cm), C (45.5%, 1.71cm) and D (0%, 0cm) (P<0.05). There was no significant difference between groups B and C (P >0.05), which indicated that quercetin inhibited the incidence and growth of ing for VEGF, bFGF and the H-ras protein product showed significant differences between groups A and B, as well as groups A and C (P < 0.05), but no significant difference between groups B and C (P>0.05).CONCLUSION Quercetin can reduce the DMBA- induced mammary carcinoma incidence and tumor growth.The following mechanisms may be recausing inhibition of proliferation of the tumor cells and tumor angiogenesis.as VEGF and bFGF, so that angiogenesis in the mammary carcinomas is suppressed, with decreased mammary MVD in the rats receiving quercetin treatment. |
| |
Keywords: | quercetin experimental mammary carcinoma VEGF H-ras angiogenesis |
本文献已被 万方数据 SpringerLink 等数据库收录! |
|