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Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins
Authors:Fang Chen  Netanel Tzarum  Xiaohe Lin  Erick Giang  Rodrigo Velázquez-Moctezuma  Elias H. Augestad  Kenna Nagy  Linling He  Mayda Hernandez  Mallorie E. Fouch  Ariadna Grinyó  Deborah Chavez  Benjamin J. Doranz  Jannick Prentoe  Robyn L. Stanfield  Robert Lanford  Jens Bukh  Ian A. Wilson  Mansun Law
Affiliation:1. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA;2. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA;3. Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark;4. Integral Molecular, Inc., Philadelphia, PA 19104, USA;5. Southwest National Primate Research Center at Texas Biomedical Research Institute, San Antonio, TX 788227, USA;6. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Abstract:
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  • Keywords:Hepatitis C virus  vaccination  immunization  E1E2  E2  broadly neutralizing antibody  antibody germline  IGHV1-69  VH1-69  VH1.36
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