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The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses
Authors:Marlieke L.M. Jongsma  Antonius A. de Waard  Matthijs Raaben  Tao Zhang  Birol Cabukusta  René Platzer  Vincent A. Blomen  Anastasia Xagara  Tamara Verkerk  Sophie Bliss  Xiangrui Kong  Carolin Gerke  Lennert Janssen  Elmer Stickel  Stephanie Holst  Rosina Plomp  Arend Mulder  Soldano Ferrone  Robbert M. Spaapen
Affiliation:1. Department of Immunopathology, Sanquin Research, Amsterdam, the Netherlands;2. Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands;3. Cancer Center Amsterdam, Amsterdam, the Netherlands;4. Oncode Institute and Department of Cell and Chemical Biology, LUMC, Leiden, the Netherlands;5. Oncode Institute, Division of Biochemistry, the Netherlands Cancer Institute, Amsterdam, the Netherlands;6. Center for Proteomics and Metabolics, LUMC, Leiden, the Netherlands;7. Institut für Hygiene und Angewandte Immunologie, Vienna, Austria;8. Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany;9. Faculty of Medicine, University of Freiburg, Freiburg, Germany;10. Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, Germany;11. Faculty of Biology, University of Freiburg, Freiburg, Germany;12. Department of Immunology, LUMC, Leiden, the Netherlands;13. Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;14. Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands;15. Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands;16. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria;17. Cancer Genomics Center, Amsterdam, the Netherlands
Abstract:
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  • Keywords:HLA class I  MHC class I  glycosphingolipids  B3GNT5  SPPL3  T cells  antigen presentation  immunotherapy  immune recognition  glioma
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