Efficacy and safety of reslizumab in the treatment of eosinophilic granulomatosis with polyangiitis |
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| Authors: | Laurie A. Manka Vamsi P. Guntur Joshua L. Denson Ryan M. Dunn Yeshai T. Dollin Matthew J. Strand Michael E. Wechsler |
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| Affiliation: | 1. Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado;2. The Cohen Family Asthma Institute, National Jewish Health, Denver, Colorado;3. Division of Pulmonary Diseases, Critical Care & Environmental Medicine, Tulane University, New Orleans, Louisiana;4. OSF HealthCare, Division of Lung and Pulmonology, Peoria, Illinois;5. Division of Biostatistics, National Jewish Health, Denver, Colorado;1. Respiratory Pathophysiology Unit, Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Pisa, Italy;2. Rheumatology Unit, University Hospital of Pisa, Pisa, Italy;3. ENT Unit, University Hospital of Pisa, Pisa, Italy;1. Department of Medicine, University of Verona and Verona University Hospital, Verona, Italy;2. Department of Medicine, Respiratory Medicine Unit and Section of Internal Medicine, University of Verona and Verona University Hospital, Verona, Italy;3. Cardio-Thoracic Department, Respiratory Unit, Integrated University Hospital, Verona, Italy;4. Department of Medicine, Specialization Course in Allergy and Clinical Immunology, University of Verona, Verona, Italy;5. Division of Rheumatology, Department of Medicine, University of Verona and Verona University Hospital, Verona, Italy;6. Allergy Unit and Asthma Center, Verona University Hospital, Verona, Italy;1. Department of Medicine, University of Verona and Verona University Hospital, Verona, Italy;2. Department of Medicine, Respiratory Medicine Unit and Section of Internal Medicine, University of Verona and Verona University Hospital, Verona, Italy;3. Cardio-Thoracic Department, Respiratory Unit, Integrated University Hospital, Verona, Italy;4. Department of Medicine, University of Verona, Specialization Course in Allergy and Clinical Immunology, Verona, Italy;5. Division of Rheumatology, Department of Medicine, University of Verona and Verona University Hospital, Verona, Italy;6. Allergy Unit and Asthma Center, Verona University Hospital, Verona, Italy;1. Division of Allergy and Immunology, University of South Florida, Tampa, Fla;2. Amaris, Paris, France;3. Amaris, London, United Kingdom;4. Global Health Economics and Outcomes Research, Teva Pharmaceuticals, Frazer, Pennsylvania, Pa;5. Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Pediatrics, Washington University, St Louis, Mo |
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| Abstract: | BackgroundEosinophilic granulomatosis with polyangiitis (EGPA), a rare vasculitis with substantial morbidity, is characterized by asthma, eosinophilia, sinusitis, pulmonary infiltrates, neuropathy, positivity for antineutrophil cytoplasmic antibody, and multiorgan vasculitis. Although treatment options previously included corticosteroids and immunosuppressants, anti–interleukin 5 therapies have gained interest in EGPA treatment. Mepolizumab was approved for and recently benralizumab was found to have safety and efficacy in EGPA.ObjectiveTo determine the safety and efficacy of reslizumab in EGPA.MethodsIn this open-label, pilot study, we evaluated the safety and efficacy of intravenous reslizumab (3 mg/kg) in EGPA in 10 subjects. Oral corticosteroid dose, adverse events, exacerbations, symptom control, disease activity, blood markers, and lung function were evaluated before, during, and after 7 monthly reslizumab treatments.ResultsReslizumab was tolerated and resulted in a significant reduction in daily oral corticosteroid (P < .05). Of the 10 subjects, 3 experienced an EGPA exacerbation during the treatment. One had a severe adverse event, requiring removal from the study.ConclusionYielding similar results to other anti–interleukin 5 biologic medications, reslizumab is generally a safe and effective treatment for EGPA that warrants further study.Trial RegistrationClinicalTrials.gov Identifier: NCT02947945. |
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