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Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses |
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| Authors: | Maryam Mukhamedova Daniel Wrapp Chen-Hsiang Shen Morgan S.A. Gilman Tracy J. Ruckwardt Chaim A. Schramm Larissa Ault Lauren Chang Alexandrine Derrien-Colemyn Sarah A.M. Lucas Amy Ransier Samuel Darko Emily Phung Lingshu Wang Yi Zhang Scott A. Rush Bharat Madan Guillaume B.E. Stewart-Jones John R. Mascola |
| Affiliation: | 1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;2. Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA;3. Institute for Biomedical Sciences, George Washington University, Washington, DC 20052, USA;4. Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA;5. Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66045, USA;6. Department of Chemical Engineering, The University of Kansas, Lawrence, KS 66045, USA |
| Abstract: |  |
| Keywords: | respiratory syncytial virus RSV fusion glycoprotein prefusion memory B cells neutralizing antibodies antibody repertoire public clonotypes cryo-EM structure |
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