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Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery
Authors:Cristina C Clement  Padma P Nanaware  Takahiro Yamazaki  Maria Pia Negroni  Karthik Ramesh  Kateryna Morozova  Sangeetha Thangaswamy  Austin Graves  Hei Jung Kim  Tsai Wanxia Li  Marco Vigano’  Rajesh K Soni  Massimo Gadina  Harley Y Tse  Lorenzo Galluzzi  Paul A Roche  Lisa K Denzin  Lawrence J Stern  Laura Santambrogio
Institution:1. Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA;2. Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA;3. Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA, USA;4. Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA;5. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;6. Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA;7. Orthopedic Biotechnology Lab, Galeazzi Orthopedic Institute for Care and Scientific Research, Milan, Italy;8. Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA;9. Department of Microbiology and Immunology, Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI, USA;10. Sandra and Edward Meyer Cancer Center, New York, NY, USA;11. Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA
Abstract:
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  • Keywords:MHC class II  diabetes  advanced glycation end products  dendritic cells  hyperinsulinemia  obesity  antigen processing and presentation  oxidative posttranslational modifications
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