Better maternal quality of life in pregnancy yields better offspring respiratory outcomes: A birth cohort |
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| Authors: | Kiwako Yamamoto-Hanada Kyongsun Pak Mayako Saito-Abe Miori Sato Yukihiro Ohya |
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| Institution: | 2. Allergy Partners of Central Indiana, Indianapolis, Indiana;4. Bernstein Clinical Research Center, LLC, Cincinnati, Ohio;3. Division of Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada;2. Department of Emergency Medicine, Indiana University Health, Inc, Muncie, Indiana;2. University of Mississippi Medical Center, Jackson, Mississippi;3. Family Allergy and Asthma, Louisville, Kentucky;4. Emory University School of Medicine, Atlanta, Georgia;2. Allergy Research Unit, Kingston Health Sciences Center–Kingston General Hospital Site, Kingston, Ontario, Canada;3. Department of Biomedical and Molecular Sciences, Queen''s University, Kingston, Ontario, Canada;2. Allergy Research Unit, Kingston Health Sciences Center – KGH Site, Kingston, Ontario, Canada;3. Department of Medicine, Queen''s University, Kingston, Ontario, Canada |
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| Abstract: | BackgroundIt is suggested that maternal mental health during pregnancy may affect offspring immune and respiratory features, based on the developmental origins of health and disease hypothesis.ObjectiveTo evaluate whether maternal quality of life (QoL) and depression during pregnancy leads to wheezing, asthma, and food allergy of the offspring at 3 years of age.MethodsWe conducted a nationwide, multicenter, prospective birth cohort study, Japan Environment and Children’s Study. All variables were collected from questionnaires. Health-related QoL was measured using the Medical Outcomes Survey Short Form–8 questionnaire with a physical component summary and a mental component summary score. We conducted logistic regression analyses to evaluate the associations of offspring’s wheezing, asthma, and food allergy with maternal QoL and depression.ResultsThere were 72,685 participants with no missing variables. Maternal physical component summary scores of the Medical Outcomes Survey Short Form–8 questionnaire were negatively associated with offspring’s asthma (adjusted odds ratio aOR], 0.99; 95% confidence interval CI], 0.99-1.00), current wheezing (aOR, 0.99; 95% CI, 0.99-0.99), and food allergy diagnoses (aOR, 0.99; 95% CI, 0.98-0.99) in children. Offspring’s wheezing and asthma were also associated with maternal depression and anxiety during pregnancy.ConclusionPoor maternal prenatal QoL increased the risk of wheezing, asthma, and food allergy in offspring. In addition, maternal depression and anxiety increased the risk of offspring’s wheezing, asthma, and food allergy. |
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