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Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Authors:Stefanie Kreutmair  Susanne Unger  Nicolás Gonzalo Núñez  Florian Ingelfinger  Chiara Alberti  Donatella De Feo  Sinduya Krishnarajah  Manuel Kauffmann  Ekaterina Friebel  Sepideh Babaei  Benjamin Gaborit  Mirjam Lutz  Nicole Puertas Jurado  Nisar P. Malek  Siri Goepel  Peter Rosenberger  Helene A. Häberle  Ikram Ayoub  Burkhard Becher
Affiliation:1. Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland;2. German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Partner Site Freiburg, 79106 Freiburg, Germany;3. Department Internal Medicine I, Eberhard-Karls University, 72076 Tuebingen, Germany;4. Université de Nantes, CHU Nantes, Pôle Anesthésie Réanimations, Service d’Anesthésie Réanimation Chirurgicale, Hôtel Dieu, 44093 Nantes, France;5. German Centre for Infection Research (DZIF), Partner Site Tuebingen, 72076 Tuebingen, Germany;6. Department of Anesthesiology and Intensive Care Medicine, Eberhard-Karls University, 72076 Tuebingen, Germany;7. Toulouse Institute for Infectious and Inflammatory Diseases, Université de Toulouse, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, UPS, 31024 Toulouse, France;8. Department of Immunology, University Hospital Zurich, 8006 Zurich, Switzerland;9. Department of Infectious and Tropical Diseases, Toulouse University Hospital, 31059 Toulouse, France
Abstract:
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  • Keywords:COVID-19  SARS-CoV-2  high-dimensional single cell analysis  immune profiling  immunophenotyping  spectral flow cytometry  biomarker  GM-CSF  HLA typing  peptide binding strength
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