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Vaccination reshapes the virus-specific T cell repertoire in unexposed adults
Authors:Yi-Gen Pan  Benjamas Aiamkitsumrit  Laurent Bartolo  Yifeng Wang  Criswell Lavery  Adam Marc  Patrick V. Holec  C. Garrett Rappazzo  Theresa Eilola  Phyllis A. Gimotty  Scott E. Hensley  Rustom Antia  Veronika I. Zarnitsyna  Michael E. Birnbaum  Laura F. Su
Affiliation:1. Department of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA;2. Corporal Michael J Crescenz VA Medical Center, Philadelphia, PA 19104, USA;3. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;4. Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;5. Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA;6. Department of Biology, Emory University, Atlanta, GA, USA;7. Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA
Abstract:
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  • Keywords:immunological memory  vaccine  yellow fever virus  TCR  CD4+  T cells  tetramers  clonal selection  unexposed human  pre-existing T cells  repertoire diversity
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