Association between cognitive function and asthma in adults |
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| Authors: | Hyo-In Rhyou Young-Hee Nam |
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| Institution: | 1. Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania;2. Department of Pulmonology/Critical Care, University Hospitals Cleveland Medical Center, Cleveland, Ohio;3. Department of Internal Medicine, University Hospitals Parma Medical Center, Parma, Ohio;4. Allergy/Immunology Associates Inc., Mayfield Heights, Ohio;1. SOS Allergology and Immunology Unit, Santo Stefano Hospital, Prato, Italy;2. UOC Gastroenterology and Digestive Endoscopy Unit, Le Scotte Hospital, Siena, Italy;4. Azienda USL Toscana Centro, Santo Stefano Hospital, Prato, Italy;1. Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran;2. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;2. Institute for Brain Sciences and Cognition, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;1. Patient-Centered Outcomes, Adelphi Values, Boston, Massachusetts;2. Health Economics and Outcomes Research, Regeneron Pharmaceuticals, Inc., Tarrytown, New York;3. Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, California |
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| Abstract: | BackgroundCognitive deficits are associated with asthma globally; however, the association between cognitive function and asthma has not been fully elucidated.ObjectiveTo assess the relationship between asthma and cognitive function.MethodsA total of 202 patients with asthma aged older than 18 years were analyzed retrospectively from August 2019 to February 2020. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) test. We compared the associations of clinical parameters with cognitive function (MoCA, ≥23 vs <23) and lung function (forced expiratory volume in 1 second FEV1], ≥70% vs <70%).ResultsOf the total participants, 89 (44.1%) indicated cognitive impairment, of whom23.1% were aged less than 65 years and 72.9% were aged 65 years or older. MoCA scores were significantly different according to age (24.91 ± 3.89 for ages <65 years vs 19.11 ± 5.11 for ages ≥65 years, P < .001) and lung function (23.29 ± 5.17 for FEV1 ≥70% vs 21.23 ± 5.21 for FEV1 <70%, P = .006), but not according to asthma control (22.35 ± 5.38 for nonsevere asthma vs 22.88 ± 4.91 for severe asthma, P = .55). Age (odds ratio OR], 1.07; 95% confidence interval CI], 1.014-1.13; P = .01), educational status (OR, 6.068; CI, 2.175-16.927; P = .001), and asthma duration (OR, 1.007; CI, 1.001-1.013; P = .02) were significantly associated with cognitive impairment.ConclusionCognitive impairment was largely observed in adults (44.1%) with asthma and was more prevalent in older adults than in younger adults. Longer asthma duration and lower lung function were more associated with cognitive dysfunction. |
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