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Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection
Authors:Wenxi Xu  Laura M. Snell  Mengdi Guo  Giselle Boukhaled  Bethany L. Macleod  Ming Li  Michael V. Tullius  Cynthia J. Guidos  Ming-Sound Tsao  Maziar Divangahi  Marcus A. Horwitz  Jun Liu  David G. Brooks
Affiliation:1. Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2M9, Canada;2. Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada;3. Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada;4. Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA;5. Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada;6. Meakins-Christie Laboratories, Department of Medicine, Department of Microbiology and Immunology, Department of Pathology, McGill International TB Centre, McGill University Health Centre, Montreal, QC H4A 3J1, Canada;7. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
Abstract:
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  • Keywords:chronic viral infection  LCMV  coinfection  CyTOF  T cell differentiation  CD4 T cells  Th17 cells  Th1 cells  neutrophil
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