Stress test of the skin: The cutaneous permeability barrier treadmill |
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Authors: | Matthias Schmuth Kenneth R Feingold Peter M Elias |
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Institution: | 1. Dermatology, Medical University Innsbruck, Innsbruck, Austria;2. Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA, USA;3. Dermatology, Veterans Affair Medical Center, University of California-San Francisco, San Francisco, CA, USA |
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Abstract: | Studying skin barrier function is central to our understanding of many skin disorders. The past decade has seen a surge of skin barrier related investigative work. Genetic, biochemical and cell biology experiments have added much evidence to the importance of the barrier in disease pathogenesis of a variety of disorders including ichthyosis, atopic dermatitis and psoriasis. However, functional assays prove ever more important to demonstrate relevance of any of these findings. A paper published by Monash and Blank 60 years ago describes a stress test of the skin barrier, measuring skin barrier recovery, a functional test of tremendous implications. This seminal paper has not been cited for almost 15 years, time to acknowledge its critical importance and to review the relevance of this method today. |
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Keywords: | epidermis metabolism permeability signalling skin stratum corneum |
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