Laugier-Hunziker syndrome: a case report of the pediatric patient and review of the literature |
| |
| Authors: | Patrycja Sputa-Grzegrzolka MD Zdzislaw Wozniak MD PhD Katarzyna Akutko MD PhD Tomasz Pytrus MD PhD Wojciech Baran MD PhD Jacek Calik MD PhD Natalia Glatzel-Plucinska MSc Zygmunt Domagala MD PhD Marzenna Podhorska-Okolow MD PhD Andrzej Stawarski MD PhD Piotr Dziegiel MD PhD |
| |
| Affiliation: | 1. Division of Anatomy, Department of Human Morphology and Embryology, Wroclaw Medical University, Poland;2. Department of Pathomorphology, Wroclaw Medical University, Poland;3. 2nd Department and Clinic of Pediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Poland;4. Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland;5. Department of Chemotherapy, Lower Silesian Oncology Center, Wroclaw, Poland;6. Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Poland;7. Division of Ultrastructure Research, Wroclaw Medical University, Poland |
| |
| Abstract: | Laugier-Hunziker syndrome (LHS) is a rare, idiopathic pigmentary disorder especially affecting the lips and oral mucosa. At present, no more than 200 cases of patients diagnosed with LHS syndrome have been described worldwide. To date, three patients under the age of 20 have been described, including the youngest patient who is a 12-year-old child. The exact etiology of LHS still remains uncertain, as there is no evidence of systemic symptoms or increased cancer risk. The final diagnosis of LHS is possible after the exclusion of other, more serious diseases involving skin-mucosal hyperpigmentation, mainly Peutz-Jeghers syndrome (PJS) and Addison's disease (AD). Herein, we present a 16-year-old patient who has been diagnosed with oral hyperpigmentation since the age of 13. We reviewed the clinical and histological findings. In addition, we discussed the differential diagnosis of mucocutaneous hyperpigmentation. |
| |
| Keywords: | |
|
|
