慢性阻塞性肺疾病发病机制的新认识

慢性阻塞性肺疾病(chronic obstructive pulmonary diseas,COPD)是一种以气流受限为特征的疾病,患者气流受限不完全可逆,并呈进行性发展.吸烟以及大气污染是导致COPD发生的主要原因.有学者假设人体内本身就存在一套"肺结构维护体系"以维持肺内结构的完整,其中包括了抗氧化系统、抗蛋白酶系统和抗凋亡系统等的作用,除此之外研究还表明自身免疫系统与COPD发病也存在着关联.弄清这些系统的作用有助于更好地认识COPD的发病机制,也为临床治疗该疾病提供更充分的理论依据.

Pathogenesis of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a disease characterized by airflow limitation that is not fully reversible and usually progressive.Cigarette smoking and air pollution are chief causes of COPD.It has been postulated that there is an intrinsic lung structure maintenance program,which may involve elements for maintaining the integrity of the adult lung.The elements are utilized to oppose oxidant stress,proteolysis and apoptosis.In addition,it is shown that antoimmune system may have some relationship with COPD.Revealing the underlying effects of these elements will be helpful for a better understanding of the pathogenesis of COPD and will provide more sufficient evidence for clinic treatment.