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| 急性白血病细胞DNA指数、DNA倍体及S期百分率临床意义的研究 | |
| 引用本文： | 纪春岩,张锑,刘海鹏,刘亚民,徐从高. 急性白血病细胞DNA指数、DNA倍体及S期百分率临床意义的研究[J]. 山东大学学报(医学版), 2000, 38(1): 90-91 |
| 作者姓名： | 纪春岩 张锑 刘海鹏 刘亚民 徐从高 |
| 作者单位： | 1. 山东医科大学附属医院血液科 2. 山东省医学科学院 3. 山东省医学情报研究所 |
| 摘 要： | 综合研究不同病期急性白血病(AL)外周血白血病细胞DNA及细胞周期的变化，探讨其与临床的关系，指导临床诊断及治疗。方法应用流式细胞术(FCM)研究46例AL DNA指数、DNA倍体及S期百分率(SP)的分布。结果AL完全缓解(CR)组DNA指数、DNA非整倍体率、SP均明显低于难治／复发组(P |
| 关 键 词： | 白血病；DNA 倍体 |
| 文章编号： | 1000-0496(2000)01-0090-02 |
| 修稿时间： | 1999-04-24 |
A CLINICAL SIGNIFICANCE OF DNA INDEX DNA PLOIDY AND SP OF ACUTE LEUKEMIA CELLS |
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| JI Chun-yan,ZHANG Ti,LIU Hai-peng. A CLINICAL SIGNIFICANCE OF DNA INDEX DNA PLOIDY AND SP OF ACUTE LEUKEMIA CELLS[J]. Journal of Shandong University:Health Sciences, 2000, 38(1): 90-91 | |
| Authors: | JI Chun-yan ZHANG Ti LIU Hai-peng |
| Affiliation: | JI Chun-yan,ZHANG Ti,LIU Hai-peng;(Dept. of Hematology. the Affiliated Hospital of Shandong Medical University) |
| Abstract: | DNA and cell cycle of leukemic cell in the peripheral blood of acute leukemia (AL) patients were studied to find their relationship with clinical features so as to guide clinical diagnosis and treatment. Methods By FCM, the DNA index,DNA ploidy and SP of 46 AL patients were studied. ResultsDNA index,DNA aneuploid and SP in CR leukemia patients were lower than those in radical/relapsed groups (P<0.05,P<0.01). DNA index and DNA aneuploidy in patients achieving CR were lower than those of patients failing to achieve CR treated immediately after diagnosis (P<0.05). Conclusion The treatment of AL patients with diploids and lower DNA index was more effective. DNA index and aneuploidy may be regarded as an important reference in prescribing chemotherapy regimens for AL. |
| Keywords: | Leukemia DNA Ploidies |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |