A METHOD FOR PRODUCING CONSTANT PLASMA CONCENTRATIONS OF DRUGS: Application to Methohexitone |
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| Authors: | McMURRAY, T. J. ROBINSON, F. P. DUNDEE, J. W. RIDDELL, J. G. McCLEAN, E. |
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| Affiliation: | Department of Anaesthetics, The Queen's University of Belfast Northern Ireland |
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| Abstract: | A delivery system in which a dilute in fusion of methohexitoneis continuously added to a smaller volume of more concentratedsolution has been used to infuse exponentially decreasing drugconcentrations at a constant rate of infusion. The constantsfor calculation of concentrations and infusion rate are described.It was possible to achieve and maintain the target plasma concentrationrequired to produce anaesthesia in conjunction with nitrousoxide in oxygen. Methohexitone is the only available drug suitablefor this technique, but it requires frequent opioid supplementationand is not the ideal drug for such a technique. |
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