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| 异基因造血干细胞移植中同种异体NK细胞的临床应用及研究进展 | |
| 引用本文： | 薛同圆,何颖芝,陆艺,张佳佳,张轩煜,忻勇杰.异基因造血干细胞移植中同种异体NK细胞的临床应用及研究进展[J].医学综述,2011,17(15):2244-2246. |
| 作者姓名： | 薛同圆 何颖芝 陆艺 张佳佳 张轩煜 忻勇杰 |
| 作者单位： | 1. 南方医科大学第二临床医学院,广州,510515 2. 南方医科大学珠江医院血液科,广州,510282 3. 南方医科大学公共卫生与热带医学学院,广州,510515 |
| 基金项目： | 广东省"大学生创新实验项目"基金(1212110001)第十一届"挑战杯"广东大学生课外学术科技作品竞赛终审决赛银奖项目 |
| 摘 要： | 杀伤细胞免疫球蛋白样受体(KIR)识别并与靶细胞表面人类白细胞抗原(HLA)Ⅰ类分子结合后转导活化性或抑制性信号,从而调节自然杀伤(NK)细胞活性。在异基因造血干细胞移植(allo-HSCT)中,当KIR识别的HLA配体缺失时,NK细胞的同种异体反应性被激活,并特异性杀伤靶细胞。NK细胞KIR分子与靶细胞HLA分子特异性识别机制参与移植物抗白血病(GvL)效应和移植物抗宿主病(GvHD)。同种异体NK细胞介导的GvL效应和降低的GvHD发生率使其适合移植。现就allo-HSCT中同种异体NK细胞的临床应用及研究进展予以综述。 |
| 关 键 词： | 杀伤细胞免疫球蛋白样受体 自然杀伤细胞 同种异体 |
The Clinical Application and Research Progress of allo-Reactive NK Cell in allo-HSCT |
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| XUE Tong-yuan,HE Ying-zhi,LU Yi,ZHANG Jia-jia,ZHANG Xuan-yu,XIN Yong-jie.The Clinical Application and Research Progress of allo-Reactive NK Cell in allo-HSCT[J].Medical Recapitulate,2011,17(15):2244-2246. | |
| Authors: | XUE Tong-yuan HE Ying-zhi LU Yi ZHANG Jia-jia ZHANG Xuan-yu XIN Yong-jie |
| Institution: | XUE Tong-yuan1,HE Ying-zhi2,LU Yi3,ZHANG Jia-jia1,ZHANG Xuan-yu1,XIN Yong-jie1,LI Yu-hua2.(1.Second School of Clinical Medicine of Southern Medical University,Guangzhou 510515,China,2.Department of Hematology,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,3.School of Public Health and Tropical Medicine of Southern Medical University,China) |
| Abstract: | Killer cell immunoglobulin-like receptors（KIRs）recognize and bind with human leukocyte antigen（HLA）class Ⅰ molecules of target cell specifically,conducting activating or inhibitory signals to regulate NK cell activity.In allo-hematopoietic stem cell transplantation（allo-HSCT）,KIR-HLA mismatch will stimulate alloreactivity of NK cell,which makes NK cell kill target cell specifically.The mechanism of KIR specifically recognizing HLA participates in graft-versus-leukemia（GvL）effect and graft-versus-host disease（GvHD）.The GvL effect and reduction of incidence of GvHD mediated by allo-reacive NK cell make it fit for transplantation.Consequently,here is to review the clinical application and research progress of alloreactive NK cell in allo-HSCT. |
| Keywords: | Killer cell immunoglobulin-like receptor Natural killer cell Allogeneic |
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