左旋肉碱与代谢综合征关系的研究进展

左旋肉碱是线粒体脂肪酸β氧化过程中的重要成分,临床上主要用于心血管疾病、肝病与男性生殖系统疾病的治疗。近来有研究表明,左旋肉碱通过促进脂肪酸进入线粒体氧化分解,提高血液中高密度脂蛋白水平等方式改善代谢综合征中肥胖、血脂紊乱、心血管疾病和高血糖的临床症状。现就其与代谢综合征的主要临床症状的关系的研究进展做简要综述。

Development of the Studies on Relationships between L-carnitine and Metabolic Syndrome

L-carnitine is an important component of the β oxidation process of mitochondrial fatty acid.It is mainly used for cardiovascular disease,liver disease and male reproductive system diseases in clinic.Recent studies have shown that L-carnitine through promoting the decomposition of fatty acids into the mitochondria,increase in blood levels of high density lipoprotein ways to improve some major symptoms of metabolic syndrome including obesity,dyslipidemia,cardiovascular disease and hyperglycemia.Here the relationship between L-carnitine and some major symptoms of metabolic syndrome were reviewed.