| 吉西他滨联合顺铂治疗晚期三阴性乳腺癌的临床观察 |
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| 引用本文： | 吴梅红,王梅,王雅杰.吉西他滨联合顺铂治疗晚期三阴性乳腺癌的临床观察[J].医学综述,2011,17(16):2522-2525. |
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| 作者姓名： | 吴梅红 王梅 王雅杰 |
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| 作者单位： | 第二军医大学附属长海医院肿瘤科,上海,200433 |
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| 摘 要： | 目的比较观察吉西他滨联合顺铂治疗晚期三阴性乳腺癌(TNBC)及非TNBC的疗效及安全性。方法 37例晚期乳腺癌患者,根据免疫组化表达情况分为TNBC组及非TNBC组,化疗方案为吉西他滨1000 mg/m2静脉滴注第1、8天;顺铂75 mg/m2静脉滴注,总量分3 d给予,每21天重复。分析TNBC及非TNBC的临床病理特征、近期疗效及不良反应。结果 37例患者总有效率为37.8%,总获益率为67.6%。其中,TNBC组有效率为37.5%及患者获益率为87.5%。两组患者无进展生存期分别为(6.6±3.1)个月和(3.7±2.0)个月(P<0.05)。两组主要不良反应表现为骨髓抑制,组间不良反应发生率差异无统计学意义(P>0.05)。结论吉西他滨联合顺铂方案对晚期乳腺癌特别是TNBC疗效确切,安全性较好。
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| 关 键 词： | 三阴性乳腺癌 吉西他滨 顺铂 化学治疗 |
Clinical Observation of Gemcitabine and Cisplatin Combined Regime in Advanced Triple-negative Breast Cancer |
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| WU Mei-hong,WANG Mei,WANG Ya-jie.Clinical Observation of Gemcitabine and Cisplatin Combined Regime in Advanced Triple-negative Breast Cancer[J].Medical Recapitulate,2011,17(16):2522-2525. |
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| Authors: | WU Mei-hong WANG Mei WANG Ya-jie |
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| Institution: | WU Mei-hong,WANG Mei,WANG Ya-jie.(Department of Oncology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China) |
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| Abstract: | Objective To observe the efficacy and safety of gemcitabine and cisplatin combined regimen in advanced triple-negative breast cancer(TNBC)versus non-TNBC.Methods 37 patients were divided into two groups according to the expression of immunohistochemistry:TNBC group and non-TNBC group.The patients received 21 days per cycle of gemcitabine 1000mg/m2 on day 1 and day 8,cisplatin 75mg/m2 was intravenously dropped from day 1 to day 3.The clinical pathological features,efficacy and the side-effects were evaluated... |
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| Keywords: | Triple-negative breast cancer Gemcitabine Cisplatin Chemotherapy |
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