| YC-1抗肝癌作用机制的研究进展 |
| |
| 引用本文： | 罗子俨.YC-1抗肝癌作用机制的研究进展[J].医学综述,2011,17(15):2288-2290. |
| |
| 作者姓名： | 罗子俨 |
| |
| 作者单位： | 苏州大学附属第三医院肝胆外科,江苏,常州213003 |
| |
| 摘 要： | 3-(5'-羟甲基-2'-呋喃基)-1-苯甲基吲唑(YC-1)是一种人工合成的化合物,近年来其抗癌作用逐渐被人们认识和研究,如抑制低氧诱导因子1(HIF-1)、细胞周期阻滞、诱导细胞凋亡、抗血管生成和抗炎性反应等。YC-1通过HIF-1和血管内皮细胞生长因子介导的抗肝癌作用已成为近年来的研究重点。通过对YC-1多种抗肝癌机制的研究,旨在进一步明确YC-1在肝癌发生、发展中的作用,为肝癌的治疗提供新的途径。现就YC-1在抗肝癌方面的作用机制予以综述。
|
| 关 键 词： | 3-(5'-羟甲基-2'-呋喃基)-1-苯甲基吲唑 原发性肝癌 低氧诱导因子1 血管内皮细胞生长因子 |
The Advancement in YC-1 Anti-hepatocellular Carcinoma Mechanisms |
| |
| LUO Zi-yan.The Advancement in YC-1 Anti-hepatocellular Carcinoma Mechanisms[J].Medical Recapitulate,2011,17(15):2288-2290. |
| |
| Authors: | LUO Zi-yan |
| |
| Institution: | LUO Zi-yan1,JIANG Jing-ting2,QIN Xi-hu1.(1.Department of Liver & Gall Surgical,Third Affiliated Hospital of Suzhou University,Changzhou 213003,China,2.Department of Tumor Biological Treatment,3.Traditional Chinese Medicine Hospital of Changzhou 213003,China) |
| |
| Abstract: | 3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole(YC-1)is an artificial complex,the role of which is studied and recognized gradually in recent years,such as inhibiting hypoxia-inducible factor 1(HIF-1),inhibition of cell cycle,inducing apoptosis,anti-angiogenesis,anti-inflammatory and so on.The anti-hepatoma mechanism of YC-1 through HIF-1 and vascular endothelial growth factor mediation has been a research focus in recent years.The aim of the studies on anti-hepatoma mechanisms of YC-1 is to identify the role of YC-1 in genesis and development of hepatocellular carcinoma further and find a new treatment.Here is to review the anti-hepatoma mechanisms of YC-1. |
| |
| Keywords: | 3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole Primary hepatocellular carcinoma Hypoxia-inducible factor-1 Vascular endothelial growth factor |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
