OX40/OX40L与疾病

OX40/OX40L是机体免疫应答过程中一对重要的协同刺激分子,参与T细胞的活化、增殖和迁移,以及生发中心的形成和树突状细胞的分化成熟。在介导肿瘤免疫应答和自身免疫疾病的发生、发展中具有重要作用。OX40只表达于活化的T细胞表面,且主要是CD4+T细胞。OX40+T细胞是抗原特异性T细胞,集中于淋巴组织的T细胞区和外周的炎性位点,非炎性相关组织及外周血中很少出现,有很强的区域特异性。OX40L能协同刺激T细胞的活化,促进B细胞产生高效价抗体和类别转化,介导OX40+T细胞向炎症部位浸润。

OX40/OX40L and Diseases

OX40/OX40L are a pair of important allostimulatory factors in the process of immune response,which participate T-cell′s activation,proliferration and migration,as well as the formation of germinal center and the dendritic cell maturation.They play an important role in mediating tumor immune response and autoimmune disease.OX40 can only be expressed on activated T cell,mainly CD4 ＋T cells.OX40＋T cells are antigenic specific T cells,which focus on T cell area of lymphatic organization and peripheral inflammatory sites,non-inflammatory organizations and rarely peripheral blood.OX40＋ cells have very strong regional specificity.OX40L can allositimulate T cell activation,promote B cells to produce high potency antibodies and category transformation,mediate OX40＋T cells to infiltrate inflammations.