小剂量咪唑安定与异丙酚在胃镜检查中的疗效比较

目的 观察小剂量咪唑安定与异丙酚在胃镜检查中的效果和安全性.方法 胃镜检查的患者125例随机分为镇静组、对照组.镇静组60例先行咽喉部局麻,再予咪唑安定静注;对照组65例先静脉推注芬太尼,再行异丙酚静注,观察两组患者对检查感受的不适程度,检查中反应情况及检查前、中、后血压,心率和血氧饱和度的变化.结果 两组患者都能顺利完成胃镜检查,没有严重不良反应的发生.镇静组对检查感受的不适程度为6.7%,而对照组为1.5%,两组无统计学意义(P＞0.05),两组检查时间、检查前与检查后血压、心率、血氧饱和度变化均无统计学差异.结论 胃镜检查中应用小剂量咪唑安定与异丙酚静注后能使整个检查过程无痛苦反应,且安全性好.但是使用小剂量咪唑安定组费用明显降低.

Compare of efficacy and safety of sedation for gastroscopy with little dose of midazolam and propofol

Objective The applicaton of little dose of midazolam and propofol for gastroscopy in patients. Methods One hundred twenty five patients were divided into sedative group and control group randomly. Sixty patients in sedative group were given pharynx local anesthesia at first, and then given intravenous midazolam. Sixty-five patients in control group were only given fentanyl at first, and then given intravenous propofol. Satisfaction and reaction during the procedure were compared with the control group. The changes of blood pressure, heart rate and blood oxygen saturation were recorded and analysed. The recovery time of sedative group. Results Both groups succeeded in Gastyoscopy and no severe negative effects. The degree of discomfort in sedative group and control group was 6.7% and 1.5% respectively, Between two groups were not significant difference(P>0.05). The examine time, blood pressure, heart rate and blood oxygen saturation before the procedure and after the procedure in both group have no significant difference in statistics. Conclusions With intravenous use of little dose of midazolam and propofol in patients, gastroscopy can be performed comfortablely and safely. But expenses of in sedative group was remarkable lower as compared with the control group.