| 黄精煎液对衰老小鼠组织端粒酶活性的影响 |
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| 引用本文： | 李友元,杨宇,邓红波,胡信群,陈珑珑. 黄精煎液对衰老小鼠组织端粒酶活性的影响[J]. 华中医学杂志, 2002, 26(4): 225-226,230 |
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| 作者姓名： | 李友元 杨宇 邓红波 胡信群 陈珑珑 |
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| 作者单位： | 410011,长沙,中南大学湘雅二医院老年病科 |
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| 摘 要： | 目的 探讨黄精煎液对衰老小鼠组织端粒酶活性的影响。方法 采用端粒重复扩增－微孔板杂交法检测衰老动物组织黄精治疗前后的端粒酶活性；采用改良TBA荧光法测定组织丙二醛（MDA）的含量。结果 黄精治疗后实验动物脑、性腺组织端粒酶活性明显升高，而其MDA含量无显著变化，MDA含量与端粒酶活性无相关性。结论 黄精可显著升高衰老动物脑和性腺组织的端粒酶活性。
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| 关 键 词： | 黄精煎液 端粒酶 衰老 抗衰老作用 丙二醛 |
Effect of ploygonatum sibiricum on telomerase activity in aging mice tissue |
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| Li Youyuan,Yang Yu,Deng Hongbo et al. Effect of ploygonatum sibiricum on telomerase activity in aging mice tissue[J]. Central China Medical Journal, 2002, 26(4): 225-226,230 |
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| Authors: | Li Youyuan Yang Yu Deng Hongbo et al |
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| Affiliation: | Li Youyuan,Yang Yu,Deng Hongbo et al. Department of Geriatrics,the Second Xiangya Hospital of Central South University,Changsha 410011 |
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| Abstract: | Objective To investigate the effect of ploygonatum sibiricum (P.sibiricum) on telomerase activity in animal tissue and the mechanism.Methods The telomerase activity in aging mice tissue before and after treatment with P. sibiricum were measured by TRAT microtiter plate hybridization method and tissue MDA was measured by modified TBA fluorescence method.Results The telomerase activity in gonad and brain in the experimental animals was significantly increased after treatment with P.sibiricum, but the MDA levels had no significant change. There was no relationship between tissue MDA levels and telomerase activity.Conclusion P.sibiricum can significantly activate the telomerase activity in brain and gonad tissue in the aging animals. |
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| Keywords: | Ploygonatum sibiricum Telomerase Aging Animal experiment |
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