| 食管癌前病变组织 Rb 和 P16 蛋白的表达 |
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| 引用本文： | 王立东,李健,李永欣,冯常炜,高珊珊.食管癌前病变组织 Rb 和 P16 蛋白的表达[J].郑州大学学报(医学版),1997(1). |
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| 作者姓名： | 王立东 李健 李永欣 冯常炜 高珊珊 |
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| 作者单位： | 河南医科大学医学实验中心癌症研究室，河南医科大学第二附属医院 |
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| 基金项目： | 国家自然科学基金,国家教委留学回国人员专项基金,河南省首批杰出青年科学基金 |
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| 摘 要： | 采用免疫组织化学方法，测定人食管正常上皮和癌前病变组织中肿瘤抑制基因Ｒｂ和Ｐ１６蛋白表达。结果：在２５例食管粘膜活检组织中，共发现８例食管正常上皮、１３例基底细胞增生和４例间变。在正常组织未见Ｒｂ和Ｐ１６免疫阳性反应，而基底细胞增生中Ｒｂ和Ｐ１６的免疫阳性反应率分别为１６％和９％，间变均为３３％。提示：食管癌变的早期阶段已发生Ｒｂ和Ｐ１６蛋白表达变化。
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| 关 键 词： | 食管癌前病变 肿瘤抑制基因 Rb P16 |
Expression of tumor suppressor gene Rb and P16 in esophageal precancerous lesions |
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| Wang Lidong ,Li Jian ,Li Yongxin ,Feng Changwei ,Gao Shanshan Laboratory for Cancer Research,Medical Experimental Center,Henan Medical University,Zhengzhou.Expression of tumor suppressor gene Rb and P16 in esophageal precancerous lesions[J].Journal of Zhengzhou University: Med Sci,1997(1). |
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| Authors: | Wang Lidong Li Jian Li Yongxin Feng Changwei Gao Shanshan Laboratory for Cancer Research Medical Experimental Center Henan Medical University Zhengzhou |
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| Institution: | Wang Lidong 1),Li Jian 1),Li Yongxin 1),Feng Changwei 2),Gao Shanshan 1) 1)Laboratory for Cancer Research,Medical Experimental Center,Henan Medical University,Zhengzhou 450052 2)Department of Internal Me |
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| Abstract: | The expression of tumor suppressor gene Rb and P16 was determined in human normal esophageal epithelium and precancerous lesions with immunohisto chemical method.Results:of the 25 esophageal mucosa biopsies,8 cases were found with normal esophageal epithelia;13 cases with basal cell hyperplasia and 4 cases with dysplasia.Immunoreactivity for Rb and P16 was not found in normal esophageal epithelium,but in basal cell hyperplasia,positive immunoreactivity for Rb and P16 was found with the rates of 16% and 9%, respectively.In dysplasia,the positive immunoreactivity rates of Rb and P16 were the same with each other (33%).The present results indicated that the expression of Rb and P16 occurred in the early stage of esophageal carcinogenesis.The biological significance of these changes need to be further characterized. |
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| Keywords: | esophageal precancerous lesions:tumor suppressor gene Rb P16 |
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