| 早幼粒细胞白血病基因的功能研究进展 |
| |
| 引用本文： | 周励,陈国强,沈志祥. 早幼粒细胞白血病基因的功能研究进展[J]. 中华医学遗传学杂志, 2000, 17(2): 132-135 |
| |
| 作者姓名： | 周励 陈国强 沈志祥 |
| |
| 作者单位： | 200025,上海第二医科大学附属瑞金医院,上海血液学研究所 |
| |
| 基金项目： | 国家杰出青年科学基金!(397250111)，国家自然科学基金!(39770410) |
| |
| 摘 要： | 为上幼粒白血病基因和维甲酸受体α（ｐｒｏｍｙｅｌｏｃｙｔｉｃ ｌｅｕｋｅｍｉａ－ｒｅｔｉｎｏｉｃ ａｃｉｄ ｒｅｃｅｐｔｏｒ α，ＰＭＬ－ＲＡＲα）的致病机理，对野生ＰＭＬ基因的生物学功能的研究进展进行综述。从近年来国内外公开发表的有关报道，结合本研究所的部分研究结果，提示ＰＭＬ的高表达有抑制细胞生长和诱导凋亡的作用；ＰＭＬ可能参与基因表达的调控；且ＰＭＬ功能的发挥与其３个重要功能区和核内定位有关
|
| 关 键 词： | 白血病 APL 维甲酸受体α 生物学功能 研究进展 |
| 修稿时间： | 1999-04-25 |
Progress in researches on the function of PML gene |
| |
| ZHOU Li,CHEN Guoqiang,SHEN Zhixiang. Progress in researches on the function of PML gene[J]. Chinese journal of medical genetics, 2000, 17(2): 132-135 |
| |
| Authors: | ZHOU Li CHEN Guoqiang SHEN Zhixiang |
| |
| Affiliation: | Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P.R.China. |
| |
| Abstract: | This paper was aimed to review and expound the progreses in studies on biological fuction of wild-type PML gene and hence to have a gain in knowledge about the carcinogenesis of PML-RARalpha protein. Related reports issued at home and abroad and some research results from this institute were collected and reviewed. According to the data collected PML gene has many biological activites. High expression of PML gene can inhibit the growth of cells and induce apoptosis; PML gene is possibly involved in the regulation of gene expression. Moreover, the function of PML gene is related to its three important domains and its nuclear location; PML gene is associated with carcinogenesis of APL. |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
