基于超声心动图的钙化性主动脉瓣疾病患病情况的回顾性研究

目的分析钙化性主动脉瓣疾病(CAVD)的患病情况。方法收集并回顾性分析行超声心动图检查年龄≥45岁患者的临床资料17 826例,男性9725例,女性8101例,其中45⁶4岁11 274例,6564岁11 274例,65⁷4岁4250例,7574岁4250例,75⁸4岁2052例,≥85岁250例。结果CAVD总患病率为12.8%,男性CAVD患病率明显高于女性(13.6%vs11.9%),CAVD发生年龄明显低于女性(70±10)岁vs(71±10)岁,P=0.001]。CAVD患病率随着年龄增长明显增高,4584岁2052例,≥85岁250例。结果CAVD总患病率为12.8%,男性CAVD患病率明显高于女性(13.6%vs11.9%),CAVD发生年龄明显低于女性(70±10)岁vs(71±10)岁,P=0.001]。CAVD患病率随着年龄增长明显增高,45⁶4岁,6564岁,65⁷4岁,7574岁,75⁸4岁,≥85岁4个年龄段患病率分别为5.3%、20.5%、32.9%和54.4%。CAVD患者最常受累及的瓣叶为无冠瓣,其次是右冠瓣+无冠瓣、右冠瓣和左冠瓣。CAVD患者常见的功能异常为主动脉瓣反流,且主动脉瓣反流较狭窄明显多见(77.1%vs 15.0%,P<0.01)。CAVD患者左心房扩大发生率明显高于左心室扩大(56.3%vs 22.2%),室间隔肥厚发生率明显高于左心室后壁(51.7%vs 24.2%,P<0.01)。结论 CAVD患病率随年龄增长显著增高。

Echocardiography-based retrospective analysis of calcific aortic valve disease

Objective To analyze the incidence of calcific aortic valve disease(CAVD).MethodsThe clinical data of 17 826 patients aged≥45years who underwent echocardiography were retrospectively analyzed.Of the 17 826 patients,9725were male,8101 were female,11 274 aged 45-64 years,4250aged 65-74 years,2052aged 75-84 years and 250aged≥85years.Results The total incidence of CAVD was 12.8%(99%CI:0.12-0.13).The incidence of CAVD was significantly higher in male patients than in female patients(13.6% vs 11.9%,P<0.05).The age to develop CAVD was younger in male patients than in female patients(70±10years vs 71±10years,P=0.001).The incidence of CAVD increased with the increasing age,and was 5.3%,20.5%,32.9% and 54.4%in 45-64,65-74,75-84and≥85years old patients.The most commonly involved aortic valve in CAVD patients was the noncoronary leaflet,followed by the right leaflet+ noncoronary leaflet,right leaflet,and left leaflet.The most common dysfunction in CAVD patients was aortic valve regurgitation.The incidence of aortic valve regurgitation was higher than that of aortic valve stenosis(77.1%vs 15.0%,P<0.01).The incidence of enlarged left atrium was higher than that of left ventricle(56.3% vs 22.2%,P<0.01).The incidence of interventricular wall hypertrophy was higher than that of left ventricle posterior wall hypertrophy(51.7%vs 24.2%,P<0.01).Conclusion The incidence of CAVD increases with increasing age.