| 化疗对卵巢恶性肿瘤患者外周血OKT—细胞亚群的影响 |
| |
| 引用本文： | 梁连铸 顾美皎. 化疗对卵巢恶性肿瘤患者外周血OKT—细胞亚群的影响[J]. 实用肿瘤杂志, 1991, 6(2): 80-82 |
| |
| 作者姓名： | 梁连铸 顾美皎 |
| |
| 作者单位： | 同济医科大学同济医院妇产科，同济医科大学同济医院妇产科 |
| |
| 摘 要： | 本文用 OKT McAb 借助 SPA-Ig 花环法测定外周血 T 细胞亚群,对13例接受化疗的卵巢恶性肿瘤患者进行动态观察。结果表明,与化疗前相比,化疗第1疗程后,T 细胞亚群无明显变化,第2～6疗程后,OKT_4细胞明显减少,OKT_8细胞显著增加,OKT_4/OKT_8比值倒置。提示化疗可能抑制机体免疫功能,卵巢癌患者进行化疗的同时,应提倡用免疫调节剂。
|
| 关 键 词： | 卵巢肿瘤 药物疗法 单克隆抗体 |
Effect of chemotherapy on OKT-cell subsets of patients with ovarian malignancies |
| |
| Liang Lian-Zbu. Effect of chemotherapy on OKT-cell subsets of patients with ovarian malignancies[J]. Journal of Practical Oncology, 1991, 6(2): 80-82 |
| |
| Authors: | Liang Lian-Zbu |
| |
| Affiliation: | Liang Lian-Zbu Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical University,Wuhan |
| |
| Abstract: | The peripheral blood T-cell subpopulation of 13 patients with ovarian malignancies was eval- uated dynamically by using the OKT-series of monoclonal antibodies and SPA-Ig rosette technique. No signifieant difference was revealed in the distribution of T-cell subsets before chemotherapy and by the end of the first course of chemotherapy in these cases.But the percentage of OKT_4 cells decreased markedly whereas that of OKT_8 cells increased significantly with the OKT_4/OKT_8 ratio reversed after 2-6 courses of chemotherapy.The result suggests that the chemotherapy may suppress the immune function of patients,and therefore,administration of immune regulator should be advocated during chemotherapy in patients with ovarian malignancies. |
| |
| Keywords: | ovarian malignancies chemotherapy T-cell subsets OKT McAb |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
