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Relationship between Glutathione S-Transferase P1 Polymorphism and Bronchial Asthma and Atopic Dermatitis |
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| Authors: | O. G. Safronova V. A. Vavilin A. A. Lyapunova S. I. Makarova V. V. Lyakhovich L. F. Kaznacheeva N. A. Manankin O. A. Batychko S. M. Gavalov |
| Affiliation: | (1) Siberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and Biophysics, Russia;(2) Novosibirsk State Medical Academy, Russia;(3) Municipal Children's Hospital No. 1, Novosibirsk |
| Abstract: | We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control). The GSTP1-Ile105/Val105 genotype determines the resistance to atopic dermatitis (odds ratio=0.51; 95% confidence interval: 0.28-0.92; p=0.023). However, both homozygotes are at high risk of developing atopic dermatitis (near-significant differences). |
| Keywords: | bronchial asthma atopic dermatitis xenobiotics glutathione S-transferase P1 polymorphism predisposition |
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