可溶性OX40配体与颈动脉内膜中膜厚度的关系

目的 观察冠心病稳定型心绞痛患者及高危因素患者血浆中可溶性OX40配体水平,同时测定颈动脉内膜中膜厚度,分析两者的相关性,进一步探讨可溶性OX40配体与冠心病的关系.方法 采用酶联免疫吸附法测定35例稳定型心绞痛患者、30例高危因素者及20例正常对照者血浆中可溶性OX40配体浓度,同时利用彩色超声仪测量颈动脉内膜中膜厚度.结果 稳定型心绞痛患者血浆可溶性OX40配体水平(24.95±15.60 ng/L)高于正常对照者(16.44±11.31 ng/L;P<0.05);稳定型心绞痛患者和高危因素者的颈动脉内膜中膜厚度高于正常对照者(P<0.05),且与血浆可溶性OX40配体显著正相关(r=0.376,P=0.001).多因素回归分析显示,在控制年龄、血脂及血压影响后,可溶性OX40配体水平对内膜中膜厚度有独立的贡献(P=0.019).结论 冠心病患者可溶性OX40配体水平显著增高,且与颈动脉内膜中膜厚度独立相关,提示可溶性OX40配体可作为判断冠心痛及动脉粥样硬化新的炎症指标.

The Association of Soluble OX40 Ligand Level and Carotid Intima-Media Thickness in Coronary Heart Disease

Aim To measure the plasma soluble OX40 ligand(sOX40L) levels and carotid intima-media thickness (IMT) in patients with coronary heart disease and age-,sex-matched controls,trying to investigate the relationship between sOX40L and coronary heart disease.Methods Enzyme-linked immunosorbent assay was used to measure plasma sOX40L in 35 patients with stable angina pectoris,30 individuals with high risk factors of coronary heart disease, and 20 age-,sex-matched healthy controls.Carotid IMT was measured with carotid ultrasonography.Results The levels of sOX40L(24.95±15.60 ng/L) was significantly higher in patients with stable angina pectoris compared with control group(16.44±11.31 ng/L;P<0.05).Patients with stable angina pectoris and risk factors had higher values of carotid IMT than controls.Multiple regression analysis indicated that sOX40L level was an independent contributor to carotid IMT(P = 0.019) after controlling age,lipid levels,and blood pressure.Conclusion sOX40L level is an independent contributor to carotid IMT,and suggests the potential diagnostic significance of sOX40L in atherosclerosis.