Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods |
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| Authors: | Zhen Shi Yazhen Wang Shaobo Dong Tianyu Lan |
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| Institution: | College of Materials Science and Engineering, Qiqihar University, Qiqihar 161006 Heilongjiang China.; Heilongjiang Provincial Key Laboratory of Polymeric Composite Materials, Qiqihar 161006 China ; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040 Heilongjiang China |
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| Abstract: | In this paper, two methods were used to prepare the magnetic targeting drug carrier Fe3O4–PVA@SH, the step-by-step method and the one-pot method. The loading and release properties of the compound were measured. The results show that the Fe3O4–PVA@SH prepared using both methods exhibited excellent drug delivery properties in an environment that simulates human body fluid (pH 7.2) and a lysosomal in vitro simulation (pH 4.7). In applications such as drug delivery, magnetic targeted drug carriers prepared by both methods demonstrated superparamagnetism, high fat solubility, high hydroxyl content, and good water solubility.Roadmap for the synthesis of Fe3O4–PVA@SH using the step-by-step method and one-pot method. |
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