颅脑损伤后钙、钙调蛋白的变化及三七总皂甙的治疗作用

目的 探讨颅脑损伤后神经细胞钙超载及钙－钙调蛋白复合物形成与三七总皂甙的治疗作用。方法 应用放射免疫法，原子吸收分光光度法测定动物血及脑组织中钙（Ｃａ＾２＋），钙调蛋白（ＣａＭ）含量，观察三七总皂甙对动物脑损伤后上述指标改变的影响，结果 知中Ｃａ＾２＋，ＣａＭ与及职Ｃａ＾２＋，ＣａＭ呈显著正相关，三七总皂甙显著降低低血与脑组织中Ｃａ＾２＋，ＣａＭ的含量，结论：三七总皂甙能阻滞脑损伤后神经细胞内钙超

Effect of Panax Notoginseng Saponin on Ca 2+ , CaM in Craniocerebral Injury

Objective: To explore the change of nerve cell Ca 2 overload, Ca 2 CaM and the effect of Panax Notoginseng saponin (PNS) on it in craniocerebral injury. Methods: Blood and brain contents of Ca 2 , CaM were examined by radio immunoassay (RIA) and atomic absorption spectrometry(AAS), and effect of PNS on these parameters was observed in craniocerebral injury rabbits. Results: The levels of Ca 2 and CaM in blood and those in brain were significantly positively correlated. PNS could reduce Ca 2 and CaM contents in blood and in cerebral tissue. Conclusion: PNS could block the Ca 2 overload and Ca 2 CaM complex production in nerve cell after cranial cerebral injury, thereby to protect the injured brain in a certain degree. Blood CaM level is an objective index for assessment of Ca 2 overload in nerve cell.