止泻补液合剂治疗小儿腹泻合并脱水的临床与实验研究

目的：观察止泻补液合剂治疗小儿腹泻合并轻，中度脱水的疗效。

Clinical and Experimental Study on Zhixie Buye Mixture in Treating Infantile Diarrhea Complicated with Dehydration

Objective: To observe the therapeutic effect of Zhixie Buye mixture (ZXBYM) on infantile diarrhea patient with mild and middle degree of dehydration. Methods: The controlled observation method was adopted in the clinical and experimental study. Results: There was no significant difference in the treatment of dehydration between the ZXBYM group and ORS group (P>0 05), while it was more effective for ZXBYM to eliminate the symptoms such as vomiting and abdominal distension (P<0 01). In addition, it was confirmed that the ion concentration of sodium, potassium, chlorine, glucose and osmotic pressure in the mixture was similar to those in ORS. Animal experiment showed that it has the effect of rat intestine peristalsis suppression and water absorption promotion in colon for ZXBYM. And there was statistical difference in antidiarrhea effect between the mixture and ORS (P<0 01). Conclusion: The ZXBYM is an effective mixture in the treatment of diarrhea with dehydration. It has a good prospect of development and application.