白龙片治疗恶性肿瘤的临床与实验研究

目的：观察白龙片以吉晚期恶性肿瘤的临床疗效并探讨其作用机理。方法：利用白龙片治疗３４例恶性肿瘤患者胺实体瘤疗效标准进行疗效分析，证定其生存质量改善情况及免疫功能的变化，并通过动物实验和细胞生物学实验观察其在体外对人淋巴细胞、小鼠腹腔巨噬细胞、人胃癌细胞等的作用。结果：临床观察３４例患者缓角率为１１．８％，缓稳率为８２．３％；生存质量改善，机体免疫力增强，治疗前后比较有显著性差异（Ｐ〈０．０５，Ｐ〈

Clinical Observation and Experimental Study on Treatment of Malignant Tumor with Bailong Tablet

Objective: To observe the clinical efficacy of treating moderate and advanced malignant tumors with the compound Chinese herbal medicine, Bailong tablet (BLT) and to explore its mechanism. Methods: Therapeutic effect of BLT in treating 34 cancer patients was analyzed according to the criteria of therapeutic effect for solid tumor, and changes on their living quality and immune function were observed clinically. In the experimental studies, the effect of BLT on human lymphocyte, celiac macrophage of mice and human gastric cancer cells in vitro were observed. Results: The total remission rate was 11.8%, the remission stationary rate was 82.3%, the living quality improved and immune function of organism enhanced, the difference between before and after treatment was significant (P<0 05 or P<0 01). Experimental study revealed that comparing with the control group, BLT can induce the activated human lymphocyte to kill target cell, promote the proliferation of T lymphocyte, activate the phagocytosis of celiac macrophage in vitro(P<0 05 or P<0 01). Conclusions: BLT has definite therapeutic effect for moderate and advanced cancer, its anti tumor effect was related to a series of cell biologic mechanisms, such as the immune function enhancement, T lymphocyte proliferation and macrophage activation.