| 牛磺胆酸钠在不同介质中及灭菌过程中的稳定性研究 |
| |
| 引用本文： | 刘莹莹,石朝周,胡永祥,郑子川,陆小红. 牛磺胆酸钠在不同介质中及灭菌过程中的稳定性研究[J]. 中国中药杂志, 1999, 24(2): 91-93 |
| |
| 作者姓名： | 刘莹莹 石朝周 胡永祥 郑子川 陆小红 |
| |
| 作者单位： | 同济医科大学药学院 武汉 430030;同济医科大学附属同济医院药剂科 武汉 430030 |
| |
| 摘 要： | 目的：考察蛇胆主要有效成分牛磺胆酸钠在２５％乙醇液中和人工胃液中及其在热压灭菌过程中的稳定性。方法：该溶液的稳定性预测采用恒温加速试验法，其含量测定借助薄层比色法。结果：２５℃时牛磺胆酸钠在２５％乙醇液中的半衰期（ｔ1/2）为６０．５７ｄ；３７℃时在人工胃液中的半衰期为１１．３７ｄ；其水溶液在１１５℃，３０ｍｉｎ灭菌条件下，牛磺胆酸钠损失率为３％。结论：牛磺胆酸钠在２５％乙醇水溶液中不稳定。建议增大乙醇浓度，并将其贮藏在０℃以下。
|
| 关 键 词： | 蛇胆 稳定性 结合胆汁酸 牛磺胆酸钠 |
| 收稿时间： | 1998-01-07 |
Studies on the Stability of Sodium Taurocholate in Different Media and in the Course of Sterilization |
| |
| Liu Yingying;Shi Chaozhou;Hu Yongxiang;Zheng Zichuan ; Lu Xiaohong. Studies on the Stability of Sodium Taurocholate in Different Media and in the Course of Sterilization[J]. China Journal of Chinese Materia Medica, 1999, 24(2): 91-93 |
| |
| Authors: | Liu Yingying Shi Chaozhou Hu Yongxiang Zheng Zichuan Lu Xiaohong |
| |
| Affiliation: | School of Pharmacy, Tongji Medical University, Wuhan 430030. |
| |
| Abstract: | OBJECTIVE: To investigate the stability of the main active constituent of snake gall sodium taurocholate, TCANa in 25% alcoholic solution and artificial gastric juice, and in the course of hot pressurized sterilization. METHOD: The stability of the solution was predicted by an accelerated isothermal test, and the content of TCANa was determined by TLC-colorimetry. RESULT: The half-time(t1/2) of TCANa in 25% alcoholic solution is 60.57 d at 25 degrees C, and in artificial gastric juice 11.37 d at 37 degrees C, the loss rate under the condition(115 degrees C, 30 min) of sterilization about 3%. CONCLUSION: TCANa in 25% alcoholic solution is unstable. Therefore it is suggested that in order to raise the stability of TCANa the alcoholic concentration be increased and the solution be stored at temperatures below 0 degree C. |
| |
| Keywords: | snake gall stability conjugated bile acids sodium taurocholate |
| 本文献已被 CNKI 维普 等数据库收录！ |
