舒关冲剂治疗中晚期类风湿性关节炎的临床与实验研究

目的：探讨舒关冲剂治疗类风湿性关节炎的作用机理。方法；以益肾蠲痹，消炎化瘀为基本治疗大法，研制了舒关温经冲剂与舒关清络冲剂，分别治疗中晚期类风湿性关节炎４４例和４３例，并以Ｗａｎｇ痹冲剂为对照，还进行了动物实验研究。结果：临床总有效率；温经组为８８．６，清络组为９３．０％，对照组为７３．２％；两冲剂能明显提高弗氏完全佐剂关节炎大鼠血清ＳＯＤ水平，降低血清白介素１，血浆前列腺素Ｅ２和血栓烷Ｂ２的含量

Clinical and Experimental Study on Effect of Shuguan Granule on Mid Late Rheumatoid Arthritis

Objective: To explore the therapeutic mechanism of Shuguan Granule (SGG) in treating mid late rhematoid arthritis. Methods: Based on the principle of reinforcing Kidney to treat arthritis, removing phlegm to remove stasis, two SGG, Shuguan Wenjing granule (SW) and Shuguan Qingluo granule (SQ) were prepared and used to treat mid late 44 and 43 patients of rheumatoid arthritis respectively. The clinical result was compared with that of Wangbi Granule. Animal experiments on the effect of the two SGG were conducted. Results: The total effective rate of the SW, SQ and control group was 88.64%, 93.02% and 73.17% respectively. Results of experimental studies in rats with adjuvant induced arthritis showed that the two SGG obviously raise the level of serum SOD, and lowered the levels of serum interleukin 1, plasma prostaglandin E 2 and thromboxane B 2, as compared with the model group, the difference was significant (P<0 05, P<0.01). Conclusion: The two SGG have a comprehensive function of anti inflammatory, analgesia, antioxidation, antihypercoagulation and immunoreglattion.