大黄治疗妊娠高血压综合征的临床观察

目的：探讨大黄对妊娠高血压综合征（ＰＩＨ）的治疗作用及其作用机理。方法：治疗组口服制大黄和心痛定，对照组单服心痛定，并观察血脂、肾功能、凝血、纤溶及免疫等指标的变化，结果：治疗组（１）血甘油三酯（ＴＧ）、低密度脂蛋白－胆固醇（ＬＤＬ－Ｃ）明显下降，高密度脂蛋白－胆固醇（ＨＤＬ－Ｃ）明显升高；（２）血浆纤维结合蛋白（ＦＮ）、纤溶酶原活性抑制因子（ＰＡＩ）明显下降，抗凝血酶Ⅲ（ＡＴ－Ⅲ）无明显变化；（

Clinical Observation on Therapeutical Effect of Prepared Rhubarb in Treating Pregnancy Induced Hypertension

OBJECTIVE: To study the effect of prepared rhubarb in treating patients with pregnancy induced hypertension (PIH) and its therapeutic mechanisms. METHODS: Prepared rhubarb and nifedipine were given to the study group, while the nifedipine was given to the control group alone. The blood lipid, renal function, blood coagulation, fibrinolysis and immunological parameters were monitored. RESULTS: In the study group, (1) Levels of triglycerides (TG) and low density lipoprotein-cholesterol (LDL-C) decreased and high density lipoprotein-cholesterol (HDL-C) level increased significantly; (2) Plasma level of fibronectin (FN) and plasminogen activator inhibitor (PAI) lowered significantly, plasma antithrombin (AT-III) level unchanged; (3) Serum beta 2 microglobulin (beta 2-MG) level and urinary level of N-acetyl-beta-D-glucosaminidase (NAG) and interleukin-6 (IL-6) decreased significantly; (4) CD8 of blood increased, CD4/CD8 and circulating immune complex (CIC) of blood reduced obviously. All of the above-mentioned parameters in the study group were significantly different from that of the control group. CONCLUSION: The prepared rhubarb could reduce the vascular endothelial cell's damage significantly and alter the immune balance, which is effective in treating the PIH.