高分辨率MRI分析基底动脉几何形态与其动脉粥样硬化斑块的相关性

目的 基于高分辨率MRI(HR-MRI)观察基底动脉(BA)几何形态与动脉粥样硬化斑块的相关性。方法 回顾性分析120例疑诊后循环缺血性脑卒中患者头颈部高分辨率MRI及MR血管造影(MRA),根据BA有无斑块分为斑块组(n=60)及对照组(n=60),并依据斑块是否高危将斑块组分为高危亚组(n=33)及非高危亚组(n=27);以单因素分析及多因素logistic回归分析筛选BA斑块及BA高危斑块的独立相关因素。绘制受试者工作特征(ROC)曲线，分析BA几何形态参数评估BA斑块及BA高危斑块的效能。结果 年龄、高血压及BA曲率均与BA斑块独立相关(P均<0.05);BA曲率及斑块负荷均与BA高危斑块独立相关(P均<0.05)。BA曲率评估BA斑块的曲线下面积(AUC)为0.70,评估BA高危斑块的AUC为0.79。结论 HR-MRI可用于观察BA几何形态；BA曲率与BA斑块及高危斑块独立相关。

High-resolution MRI for analysis of relationship between geometry of basilar artery and atherosclerotic plaque

Objective To investigate the relationship between geometry of basilar artery (BA) and atherosclerotic plaque based on high-resolution MRI (HR-MRI). Methods Head and neck HR-MRI and MR angiography (MRA) data of 120 patients with suspected posterior circulation ischemic stroke were retrospectively analyzed. According to the presence or not of BA plaque, the patients were divided into plaque group (n=60) and control group (n=60), while patients in plaque group were further divided into high-risk plaque subgroup (n=33) and non-high-risk plaque subgroup (n=27) based on the plaque being high-risk or not. Univariate analysis and multivariate logistic regression analysis were used to screen the independent relative factors of BA plaque and high-risk BA plaque. Receiver operator characteristic (ROC) curves were drawn, and the value of BA geometry for evaluating BA plaque and high-risk BA plaque were analyzed. Results Age, hypertension and BA tortuosity were independently associated with BA plaque (all P<0.05). BA tortuosity and plaque burden independently associated with high-risk BA plaque (both P<0.05). The area under the curve (AUC) of BA tortuosity for evaluating BA plaque and BA high-risk plaque was 0.70 and 0.79, respectively. Conclusion HR-MRI could be used to observe the geometry of BA. BA tortuosity independently correlated with BA plaque and high-risk BA plaque.