围绝经期子宫内膜异位症及其恶变问题

相较于绝经前子宫内膜异位症(简称内异症),由于发生率的降低,围绝经期和绝经后内异症往往更易被忽视.绝经后内异症的恶变潜能目前已被广泛认可并取得临床证据支持.内异症恶变多数发生在卵巢,少数为卵巢外的内异症相关癌.内异症相关卵巢癌(EAOC)具有其特殊的发病机制及临床特征,但其治疗方案仍然遵循普通上皮性卵巢癌治疗原则.近年...

Perimenopausal endometriosis and endometriosis-associated malignancy

Compared with premenopausal endometri-osis,perimenopausal and postmenopausal endometri-osis are often more under-recognized because of lowincidence. The malignant potential of postmenopausalendometriosis has been widely known and supported byclinical evidence. Malignant transformation of endo-metriosis mostly occurs in the ovary,and a few arecancers related to endometriosis outside the ovary. Thecurrent treatment plan for endometriosis—associatedovarian cancer(EAOC)is still the same as that of or-dinary epithelial ovarian cancer although EAOC has itsspecial pathogenesis and clinical features.In recentyears,great progress has been made in its molecularbiological mechanism,which may predict the risk ofmalignant transformation to ovarian cancer,and in-fluence the clinical decision. We may be able to designa risk assessment model for the malignant transfor-mation of endometriosis and select appropriate indi-vidualized clinical strategies for patients with endo-metriosis.