红色诺卡氏菌细胞壁骨架治疗子宫颈高级别鳞状上皮内病变的安全性和疗效研究

目的 探讨子宫颈外用红色诺卡氏菌细胞壁骨架(Nocardia rubra cell wallskeleton,Nr-CWS)治疗子宫颈高级别鳞状上皮内病变(HSIL)的安全性、耐受性和有效性.方法 选取2017年4月至2018年3月在北京大学第一医院妇产科宫颈中心就诊的子宫颈HSIL患者,回顾性分析子宫颈环形电切除术(...

Safety and efficacy of Nocardia rubra cell wall-skeleton in the treatment of cervical HSIL

ObjectiveTo explore the safety,tolerability and effectiveness of Nr-CWS in the treatment of cervical HSIL.MethodsWe retrospectively analyzed the information on complaints,cervical cytology,HPV,colposcopy andpathology after treatment in patients with cervical HSIL who were treated by LEEP(n=68)and Nr-CWS(n=50),toevaluate the safety,tolerability and efficacy. The logistic regression was used to correct possible confounding factors.ResultsCompared with the LEEP group,there were fewer patients with vaginal bleeding(P<0.001)and lowerabdominal discomfort in the Nr-CWS group(P=0.017),but more patients had increased vaginal discharge(P=0.025)inNr-CWS group. There were no statistical differences in cytological normal rate,HPV negative rate or double negativerate between the two groups at 6 and 12 months after treatment. Logistic regression was used to correct confoundingfactors such as age and pathological grade,showing that the two treatments had no significant difference on patients’ outcomes.ConclusionCervical external Nr-CWS is a safe,tolerable and effective method in the treatment ofcervical HSIL. It can be used as a treatment option for cervical HSIL.