乌司他丁对胃肠道恶性肿瘤术后化疗患者疗效的观察

目的 探讨乌司他丁在胃肠道恶性肿瘤术后化疗中应用的临床疗效.方法 选取60例胃肠道恶性肿瘤术后化疗患者随机分成乌司他丁治疗组（U组）和对照组（C组）.每天化疗前治疗组应用乌司他丁20万U,而对照组使用0.9%氯化钠溶液250ml.观察两组在化疗前、后外周血白细胞计数及血清丙氨酸氨基转移酶（ALT）、肿瘤坏死因子（TNF-α）和白介素-6（IL-6）水平的变化.结果 化疗后U组组白细胞下降的水平较C组低;血清ALT水平较化疗前均明显升高,但U组升高的幅度小于C组,且U组指标恢复速度更快;化疗后第6天IL-6 和TNF-α浓度U组明显低于C组,差异均有统计学意义（均P＜0.05）.结论 化疗期间使用乌司他丁可以减轻骨髓抑制,保护肝脏功能,减少化疗副反应.

Clinical effects of ulinastatin in patients with gastrointestinal cancer after surgical operations undergoing adjuvant chemotherapy

Objective To explore clinical curative effects of ulinastatin in patients with gastrointestinal cancer undergoing adjuvant chemotherapy. Methods Thirty patients with gastrointestinal cancer who underwent surgical operations from January 2004 to June 2006 were randomly divided into therapeutic group and control group, receiving ulinastatin 20,000 U per day or 250ml hydrochloric sodium before chemotherapy for 5 continuous days respectively. The count of white blood cell in blood and the levels of alanine aminotransferase （ALT）, TNF-α and IL-6 in serum were compared between thetwo group. Results There were no difference in the clinicopathological characteristics between the two group. The level of white blood cell decline was low- er in therapeutic group than those in control group. The level of ALT in both groups obviously elevated after chemotherapy. Compared with control group, the decreased velocity in therapeutic group was remarkable quick, serum TNF- α and IL-6 concentration in therapeutic group were significantly lower than those in control group on the 6 day after chemotherapy（P〈0.05 ）. Conclusion Utinastatin can reduce bone marrow depression ,protect liver function, for patients.