| 埃索美拉唑对氯吡格雷高维持量作用的影响 |
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| 引用本文： | 刘琼华,毛永连,张军,刘利.埃索美拉唑对氯吡格雷高维持量作用的影响[J].中国药业,2011,20(12):21-23. |
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| 作者姓名： | 刘琼华 毛永连 张军 刘利 |
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| 作者单位： | 1. 湖南省娄底市第一人民医院,湖南娄底,417009
2. 湘潭大学化工学院,湖南湘潭,411100 |
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| 摘 要： | 目的评价埃索美拉唑对非ST段抬高急性冠脉综合征(NSTE-ACS)患者支架置入术后应用氯吡格雷效果的影响。方法将102例患者随机均分为对照组和埃索美拉唑组,出院时均给予阿司匹林75 mg和氯吡格雷150 mg长期口服,埃索美拉唑组另给予埃索美拉唑20 mg口服,每日2次。以磷酸化血小板血管扩张剂刺激磷蛋白(VASP)磷酸化程度计算的血小板反应指数(PRI)用于评估氯吡格雷效果和对二磷酸腺苷(ADP)诱导的血小板聚集反应性(ADP-Ag)。结果随访1个月,埃索美拉唑组患者血小板氯吡格雷反应性与对照组有同样的效果,PRI VASP为(37.3±5.8)%对(39.4±6.3)%,P>0.05;血小板聚集反应性埃索美拉唑组与对照组有同样的效果,ADP-Ag为(51.3±14.6)%对(52.7±15.3)%,P>0.05。结论对于接受氯吡格雷治疗且同时需要质子泵抑制剂治疗时,建议应尽可能选择对CYP2C19抑制效力小的埃索美拉唑。
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| 关 键 词： | 埃索美拉唑 氯吡格雷 非ST段抬高急性冠脉综合征 血管扩张剂刺激磷蛋白 血小板聚集反应性 |
Influence of Esomeprazole on High Sustaining Dose Action of Clopidogrel |
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| Liu Qionghua,Mao Yonglian,Zhang Jun,Liu Li.Influence of Esomeprazole on High Sustaining Dose Action of Clopidogrel[J].China Pharmaceuticals,2011,20(12):21-23. |
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| Authors: | Liu Qionghua Mao Yonglian Zhang Jun Liu Li |
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| Institution: | Liu Qionghua1,Mao Yonglian1,Zhang Jun2,Liu Li2(1.People's Hospital of Loudi City,Loudi,Hunan,China 417009,2.School of Chemical Engineering,Xiangtan University,Xiangtan,China 411100) |
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| Abstract: | Objective To investigate the influence of esomeprazole on application effect of clopidogrel after stent implantation in non-ST-segment elevation acute coronary syndromes(NSTE-ACS).Methods A total of 102 patients undergoing coronary stenting for NSTE-ACS were prospectively divided into to the control group and the esomeprazole group randomly and evenly.At discharge from hospital,all the cases received 75 mg aspirin and 150 mg clopidogrel for long-term oral administration.In addition,the esomeprazole group wa... |
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| Keywords: | esomeprazole clopidogrel non-ST-segment elevation acute coronary syndrome vasodilator-stimulated phosphoprotein(VASP) ADP-induced platelet aggregation |
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