| 人工牛黄甲硝唑胶囊中甲硝唑溶出度的测定 |
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| 引用本文： | 韦广辉.人工牛黄甲硝唑胶囊中甲硝唑溶出度的测定[J].中国药业,2011,20(14):34-35. |
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| 作者姓名： | 韦广辉 |
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| 作者单位： | 广西壮族自治区食品药品监督管理局药品认证审评中心,广西南宁,530022 |
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| 摘 要： | 目的建立人工牛黄甲硝唑胶囊中甲硝唑溶出度的测定方法。方法采用紫外分光光度法,检测波长为277 nm,测定人工牛黄甲硝唑胶囊中甲硝唑的体外溶出度。结果甲硝唑的质量浓度在4.22～20.10μg/mL范围内与吸光度呈良好的线性关系(r=0.999 8),平均回收率为99.00%,RSD为0.55%(n=6)。结论该方法操作简便、结果准确、重现性好,可用于人工牛黄甲硝唑胶囊中甲硝唑溶出度的测定。
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| 关 键 词： | 人工牛黄甲硝唑胶囊 溶出度 测定 |
Determination on Dissolution Rate of Metronidazole in Galculus Bovis and Metronidazole Capsules |
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| Wei Guanghui.Determination on Dissolution Rate of Metronidazole in Galculus Bovis and Metronidazole Capsules[J].China Pharmaceuticals,2011,20(14):34-35. |
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| Authors: | Wei Guanghui |
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| Institution: | Wei Guanghui(Guangxi Center for Drug Evaluation and Authentication,Nanning,Guangxi,China 530022) |
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| Abstract: | Objective To establish the determination method of the dissolution rate of metronidazole in Galculus Bovis and Metronidazole Capsules.Methods The UV spectrophotoretric method was adopted for detection of dissolution rate at the wavelength 277 nm.Results The linear range of metronidazole was 4.22-20.10 μg/mL（r=0.999 8）.The average recovery rate of metronidazole was 99.00%,RSD=0.55%（n=6）.Conclusion The method is simple,rapid and accurate with good reproducibility,which can meet the demand determining the dissolution rate of metronidazole in Galculus Bovis and Metronidazole Capsules. |
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| Keywords: | galculus bovis and metronidazole capsules dissolution rate determination |
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