| 川楝子致小鼠肝毒性时效、量效关系研究 |
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| 引用本文： | 齐双岩,熊彦红,金若敏.川楝子致小鼠肝毒性时效、量效关系研究[J].时珍国医国药,2008,19(11). |
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| 作者姓名： | 齐双岩 熊彦红 金若敏 |
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| 作者单位： | 1. 上海中医药大学药物安全评价研究中心,上海,201203
2. 上海中医药大学中药学院,上海,201203 |
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| 基金项目： | 上海市科学技术委员会科研计划项目(No.05DZ19736) |
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| 摘 要： | 目的研究川楝子致小鼠肝毒性的时效、量效关系。方法小鼠灌服不同剂量川楝子,测定其LD50。另取小鼠按不同时间点或不同剂量分组,检查血清ALT,AST,计算肝、脾、胸腺脏器指数,并观察肝组织形态变化。结果小鼠灌服川楝子的LD50为200 g.kg-1。ALT,AST在给药后1 h达到高峰,24 h可恢复近正常值。与正常组比较,川楝子81,166 g/kg剂量组对肝组织产生明显损伤,且随着剂量增大,ALT,AST升高显著(P<0.05或P<0.01)。结论小鼠单次灌服一定剂量川楝子可造成急性肝损伤甚至死亡,并显示有毒性时效、量效关系。
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| 关 键 词： | 川楝子 小鼠 肝毒性 |
Time - dose - effect Studies on Hepatotoxicity of Mice Induced by Fructus Toosendan |
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| QI Shuang-yan,XIONG Yan-hong,JIN Ruo-min.Time - dose - effect Studies on Hepatotoxicity of Mice Induced by Fructus Toosendan[J].Lishizhen Medicine and Materia Medica Research,2008,19(11). |
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| Authors: | QI Shuang-yan XIONG Yan-hong JIN Ruo-min |
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| Institution: | 1.Research Center of Animal Safety Evaluation;Shanghai University of TCM;Shanghai 201203;China;2.School of Chinese Materia Medica;China |
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| Abstract: | Objective To study the time-effect relation and dose-effect relation of hepatotoxicity induced by Fructus Toosendan in mice.Methods The medial lethal dose(LD50) of mice was calculated after different doses of Fructus Toosendan was given orally.Then the mice were divided into different groups according to different doses or time,and the contents of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST)were investigated,the thymus,liver and spleen were weighed,and the liver tissue was studied wit... |
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| Keywords: | Fructus Toosendan Mice Hepatotoxicity |
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